Composite glandular-carcinoid tumors of the colon and rectum. Report of two cases

• Published in: The American journal of surgical pathology Vol. 12; no. 8; p. 607
• Main Authors: Moyana, T N, Qizilbash, A H, Murphy, F
• Format: Journal Article
• Language: English
• Published: United States 01.08.1988
• Subjects: Adenoma - surgery; Adenoma - ultrastructure; Aged; Carcinoid Tumor - surgery; Carcinoid Tumor - ultrastructure; Colonic Polyps - surgery; Colonic Polyps - ultrastructure; Female; Humans
• ISSN: 0147-5185; 1532-0979
• DOI: 10.1097/00000478-198808000-00001

Composite glandular-carcinoid tumors of the large bowel are rare. We describe two cases that appeared to be at a relatively early stage in their development. Each of these cases was a composite colorectal adenoma-carcinoid--an entity that has not previously been described. There was no evidence of inflammatory bowel disease (IBD) in either of these cases; and a review of the literature on composite adenocarcinoma-carcinoid neoplasms of the colon and rectum revealed only two cases that arose in a background of IBD. Thus, despite the association of IBD, especially long-standing ulcerative colitis, with epithelial dysplasia and mucosal endocrine cell hyperplasia, respectively, we believe that other factors more significant than IBD may be operative in the genesis of composite glandular-carcinoid tumors of the large bowel. Further documentation of these tumors is needed in order to better appreciate their clinicopathologic manifestations and associations.