Synthesis, Characterization and Cytotoxic Effect of Some New Thiazolyl Hydrazone Derivatives of 1-Indanone

In the present study, a series of twelve thiazolyl hydrazone derivatives of 1-indanone was synthesized and characterized by various spectroscopic techniques such as UV-Visible, NMR, IR and Mass Spectrometry. All the synthesized target compounds were subjected to MTT assay for cytotoxicity screening...

Full description

Saved in:
Bibliographic Details
Published inJournal of the Chemical Society of Pakistan Vol. 43; no. 2; p. 244
Main Authors Urooj Nazim, Urooj Nazim, Silpa Narayanan, Silpa Narayanan, Mohsin Ali, Mohsin Ali, Khalid Mohammed Khan, Khalid Mohammed Khan, Basharat Ali, Basharat Ali, Jonathan Li, Jonathan Li, Zhe Sheng Chen, Zhe Sheng Chen, Mansoor Ahmed and Dong Hua Yang, Mansoor Ahmed and Dong Hua Yang
Format Journal Article
LanguageEnglish
Published Knowledge Bylanes 30.04.2021
Subjects
Cancer
Care and treatment
Oncology, Experimental
Online AccessGet full text

Cover

More Information
Summary:In the present study, a series of twelve thiazolyl hydrazone derivatives of 1-indanone was synthesized and characterized by various spectroscopic techniques such as UV-Visible, NMR, IR and Mass Spectrometry. All the synthesized target compounds were subjected to MTT assay for cytotoxicity screening and evaluation of their anti-cancer activity on various cell lines of human cancer including glioblastoma (SNB-19), prostate cancer (PC-3), Lung cancer (NCI-H460), human ovarian carcinoma (SK-OV-3 and IGROV-1), human leukemia (K-562) and human colon cancer(HCT116).Three synthesized compounds showed promising anti-cancer activity against the colon cancer cell HCT 116 cells with IC50 ranging from 1.25and#177;0.02 to 5.04and#177;0.2 and#181;M. On the other hand all the compounds didn’t show cytotoxic activity against other forms of human cancer cells.
ISSN:0253-5106
DOI:10.52568/000564