Prevalence of hepatitis B and hepatitis C viral infections and impact of control program among blood donors in Al-Baha region, Saudi Arabia

• Published in: Saudi Journal for Health Sciences Vol. 9; no. 1; pp. 56 - 60
• Main Authors: Sallam, Talal, El-Bingawi, Haitham, Alzahrani, Khalid, Alzahrani, Bader, Alzahrani, Atyah
• Format: Journal Article
• Language: English
• Published: Wolters Kluwer India Pvt. Ltd 01.01.2020; Wolters Kluwer Medknow Publications
• Subjects: al-baha; blood donors; hepatitis b virus; hepatitis c virus; kingdom of saudi arabia; Al-Baha; hepatitis C virus; blood donors; Kingdom of Saudi Arabia; hepatitis B virus
• ISSN: 2278-0521; 2278-0521
• DOI: 10.4103/sjhs.sjhs_197_19

Background: A low prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections has been previously reported in Al-Baha. The present study reexamines the prevalence of HBV and HCV infection among blood donors 3 years following a previous study in an attempt to detect an impact of control measures. Materials and Methods: This 29-month retrospective study was conducted from October 2014 to May 2017. A total of 3,461 blood donors were screened for serological and molecular markers for HBV and HCV. Results: The mean age of the donors was 32.4 ± 10. 1 (range: 17-67). Of all donors 10 (0.3%) had HBsAg while 253 (7.3%) had anti-HBc in absence of HBsAg. Anti-HCV was detected in 8 (0.2%) donors, of whom 6 (75.0%) were also HCV-RNA positive. HBV-DNA was detected in 12 (0.4%) donors, of whom 10 (83.3%) had concurrent HBsAg, whereas 2 (16.7%) had HBV-DNA with anti-HBc as the only HBV marker. The donors born after inclusion of HBV vaccine in expanded program of immunization (EPI) had a significantly (P < 0.05) lower prevalence of HBsAg, anti-HBc, and HBV-DNA. Although insignificant (P = 0.197), a lower prevalence of HCV infection was detected among the donors who were born after implementing the screening policy for HCV infection. Conclusion: Compared to a previous report, this study detected a further reduction in the prevalence of HBV, whereas the decline of the prevalence of HCV infection merits further investigation.