Food Fails to Suppress Ghrelin Levels in Obese Humans
Ghrelin is the first circulating hormone shown to stimulate feeding in humans following systemic administration. Food consumption decreases circulating ghrelin concentrations in lean subjects but the effects of feeding have not been studied in the obese. Methods: We investigated the effects of a tes...
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Published in | The journal of clinical endocrinology and metabolism Vol. 87; no. 6; p. 2984 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Bethesda, MD
Endocrine Society
01.06.2002
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Subjects | |
Online Access | Get full text |
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Summary: | Ghrelin is the first circulating hormone shown to stimulate feeding
in humans following systemic administration. Food consumption decreases
circulating ghrelin concentrations in lean subjects but the effects of
feeding have not been studied in the obese. Methods: We investigated
the effects of a test meal on plasma ghrelin and leptin concentrations
in 13 lean and 10 obese subjects. Results: Fasting ghrelin was
significantly higher in lean than in obese subjects (857 pmol/1 vs. 325
pmol/l, (p = 0.002) and fell by 39.5% thirty minutes after eating in
the lean group before returning rapidly towards baseline values: (p =
0.003). There was no change in circulating ghrelin in the obese group.
Circulating leptin concentration also fell acutely 15 minutes following
food intake in lean but not obese subjects (p < 0.0001). Conclusions:
Obese subjects do not exhibit the decline in plasma ghrelin and leptin
seen after a meal in the lean. The role of the decline in leptin is
unclear but given the orexigenic properties of ghrelin, the lack of
suppression following a meal obese subjects could lead to increased
food consumption and suggest that ghrelin may be involved in the
pathophysiology of obesity. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0021-972X 1945-7197 |
DOI: | 10.1210/jcem.87.6.8738 |