The evaluation of low dose pre-operative X-ray therapy in the management of operable rectal cancer; results of a randomly controlled trial

824 patients with operable rectal carcinoma were randomly allocated to be treated by surgery alone, 2000 rad in 10 daily fractions and 500 rad as a single fraction. No difference has been demonstrated in the actuarial survival rates to 5 years. The local recurrence-free and metastasis-free rates are...

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Bibliographic Details
Published inBritish journal of surgery Vol. 71; no. 1; p. 21
Format Journal Article
LanguageEnglish
Published England 01.01.1984
Subjects
Clinical Trials as Topic
Combined Modality Therapy
Humans
Postoperative Complications - epidemiology
Preoperative Care
Radiotherapy Dosage
Random Allocation
Rectal Neoplasms - mortality
Rectal Neoplasms - radiotherapy
Rectal Neoplasms - surgery
Time Factors
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Summary:824 patients with operable rectal carcinoma were randomly allocated to be treated by surgery alone, 2000 rad in 10 daily fractions and 500 rad as a single fraction. No difference has been demonstrated in the actuarial survival rates to 5 years. The local recurrence-free and metastasis-free rates are similar in all groups. There is also no evidence that the pre-operative radiotherapy benefited patients in subgroups by Dukes' stage. The complication rates were also similar in the three treatment groups.
ISSN:0007-1323
DOI:10.1002/bjs.1800710107