Preparations, characterizations and applications of chitosan-based nanoparticles

Chitosan is a natural polysaccharide prepared by the N-deacetylation of chitin. In this paper we have reviewed the methods of preparation of chitosan-based nanoparticles and their pharmaceutical applications. There are five methods of their preparations: emulsion cross-linking, emulsion-droplet coal...

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Bibliographic Details
Published inJournal of Ocean University of China Vol. 6; no. 3; pp. 237 - 243
Main Authors Liu, Chenguang, Tan, Yulong, Liu, Chengsheng, Chen, Xiguang, Yu, Lejun
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Nature B.V 01.07.2007
College of Marine Life Science, Ocean University of China, Qingdao 266003, P. R. China
Subjects
Nanoparticles
chitosan
nanoparticle
delivery system
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Summary:Chitosan is a natural polysaccharide prepared by the N-deacetylation of chitin. In this paper we have reviewed the methods of preparation of chitosan-based nanoparticles and their pharmaceutical applications. There are five methods of their preparations: emulsion cross-linking, emulsion-droplet coalescence, ionic gelation, reverse micellar method and chemically modified chitosan method. Chitosan nanoparticles are used as carriers for low molecular weight drug, vaccines and DNA. Releasing characteristics, biodistribution and applications are also summarized.[PUBLICATION ABSTRACT]
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1672-5182
1993-5021
1672-5174
DOI:10.1007/s11802-007-0237-9