The APOA5‐rs662799 Polymorphism Is a Determinant of Dyslipidemia in Vietnamese Primary School Children

• Published in: Lipids Vol. 55; no. 6; pp. 683 - 691
• Main Authors: Hanh, Nguyen T. H., Nhung, Bui T., Hop, Le T., Tuyet, Le T., Dao, Duong T. A., Thu, Nguyen T. T., Binh, Tran Quang
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.11.2020
• Subjects: alleles; Apolipoprotein A5; blood serum; body mass index; case-control studies; Dyslipidemia; elementary schools; gender; Genetic variance; genotype; hip circumference; hypertriglyceridemia; lipid metabolism; obesity; odds ratio; regression analysis; restriction fragment length polymorphism; risk; rs662799; Vietnam; Vietnamese children; waist circumference; waist-to-hip ratio; Vietnam
• ISSN: 0024-4201; 1558-9307; 1558-9307
• DOI: 10.1002/lipd.12270

Apolipoprotein A‐V encoded by apolipoprotein 5 (APOA5) gene plays an important role in lipid metabolism, especially in the regulation of plasma triglycerol levels. The study aimed to evaluate the association of the APOA5‐rs662799 polymorphism with dyslipidemia in Vietnamese children and the potential modification of obesity‐related traits (body mass index, waist circumference, hip circumference, and waist‐to‐hip ratio) on this association. A case–control study was conducted with a total of 154 dyslipidemia cases and 389 controls at the age of 6 to 10 recruited at 31 primary schools in Hanoi city of Vietnam. Genotype for APOA5‐rs662799 polymorphism was determined by the restriction fragment length polymorphism analysis. The association of APOA5‐rs662799 polymorphism with dyslipidemia adjusting for age, sex, residence, and obesity‐related traits was analyzed by binary logistic regression analysis. The results showed that in comparison with T/T and T/C carriers, the C/C carriers had a higher concentration of serum TAG in cases (p =0.049). Carriers of the C allele (C/C + T/C) had higher risk for developing dyslipidemia and hypertriglyceridemia than subjects with T/T genotype (odds ratio, OR = 1.7, p =0.0062 and OR = 1.6, p = 0.026, respectively). The association remained significant after adjusting for age, gender, residence, and obesity status (OR = 1.75, p = 0.006 and OR = 1.53, p = 0.049, respectively) or other obesity‐related traits. The study suggested that the APOA5‐rs662799 polymorphism may be a determinant of dyslipidemia and hypertriglyceridemia in Vietnamese children, independent of obesity‐related traits.