Sulphadiazine/Trimethoprim Once Daily in Maxillary Sinusitis: A Randomized Double-Blind Comparison with Sulphamethoxazole/Trimethoprim B.I.D

In a randomized double-blind study fifty-four patients suffering from acute maxillary sinusitis were treated for 10 days with daily doses of sulphadiazine/trimethopim (1 g) and sulphamethoxazole/trimethoprim (1.92 g), respectively. The efficacy was evaluated clinically at two follow-up visits. X-ray...

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Bibliographic Details
Published inJournal of international medical research Vol. 9; no. 6; pp. 478 - 481
Main Authors Federspil, Pierre, Bamberg, Peter
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 1981
Subjects
Adult
Aged
Clinical Trials as Topic
Double-Blind Method
Drug Combinations - administration & dosage
Female
Humans
Male
Maxillary Sinus
Middle Aged
Random Allocation
Sinusitis - drug therapy
Sulfadiazine - administration & dosage
Sulfamethoxazole - administration & dosage
Trimethoprim - administration & dosage
Trimethoprim, Sulfamethoxazole Drug Combination
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Summary:In a randomized double-blind study fifty-four patients suffering from acute maxillary sinusitis were treated for 10 days with daily doses of sulphadiazine/trimethopim (1 g) and sulphamethoxazole/trimethoprim (1.92 g), respectively. The efficacy was evaluated clinically at two follow-up visits. X-ray investigations were performed at admission and after the therapy. Of thirty-nine patients finally evaluated, thirty-seven showed a favourable result. After 6–8 days of therapy there was significant difference in cure rates in favour of sulphadiazine/trimethoprim (p < 0.05) while the outcome as evaluated after treatment was similar for both drugs.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-News-3
content type line 23
ISSN:0300-0605
1473-2300
DOI:10.1177/030006058100900609