The impact of the association between Val16Ala-SOD2 SNP and SOD2 immunohistochemistry expression in the prognosis of patients with esophageal cancer

• Published in: Pathology, research and practice Vol. 253; p. 154965
• Main Authors: Dos Santos, A V, Kaul, A J, Dos Santos, G T, Dal Berto, M, Manfroi, L M, Rizzotto, G, Roehe, A V, Alves, R C S, Lutz, A, Beck, P, Alves, R J V, Cruz, I B M, Bica, C G
• Format: Journal Article
• Language: English
• Published: Germany 01.01.2024
• Subjects: Esophageal Neoplasms - genetics; Genotype; Humans; Immunohistochemistry; Polymorphism, Single Nucleotide; Prognosis; Superoxide Dismutase - genetics; Superoxide Dismutase 2; Biomarker; SOD2; Esophageal cancer
• ISSN: 0344-0338; 1618-0631
• DOI: 10.1016/j.prp.2023.154965

Esophageal cancer is an extensive public health issue worldwide, warranting the search for biomarkers related to its risk and progression. Previous studies have indicated an association between Val16AlaSOD2 single nucleotide polymorphism in the gene encoding the enzyme superoxide dismutase 2 and esophageal cancer. However, further investigations are needed to clarify its role in disease risk and progression. To investigate the role of Val16AlaSOD2-SNP in esophageal cancer progression and in the survival of patients METHODS: Tumor samples were utilized for Val16Ala-SNP genotyping, while SOD2 expression levels in tissue were assessed using immunohistochemistry. A SOD2 Val16Ala-SNP database was used to obtain information on the genotype of healthy individuals. Risk and overall survival analyzes were performed. The Val16Ala SNP was associated with an increased risk of esophageal cancer (RR 2.18, 95%CI 1.23-3.86), regardless of age and gender, but did not have a significant effect on patient survival. In contrast, weak SOD2 expression demonstrated a significantly associated with poor overall survival after treatment, independent of other clinicopathological variables (HR, 0.41; 95% CI, 0.22-0.79 P = 0.007). Val16Ala SNP was positively associated with esophageal cancer, and the expression of SOD2 was an independent prognostic marker.