Cu(OAc)2 mediated mild synthesis of 2-aminobenzimidazoles and 2-aminobenzoxazoles

An efficient and facile synthesis for 2-aminobenzimidazoles and 2-aminobenzoxazoles has been reported. Thioureas prepared from the reaction of o-phenylenediamines or 2-aminophenols and isothiocyanate derivatives, underwent desulfurization reaction smoothly under mild conditions in the presence of Cu...

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Bibliographic Details
Published inSynthetic communications Vol. 52; no. 7; pp. 1050 - 1058
Main Authors Han, Lei, Gan, LinLing, Hu, Xiangnan, Li, Wei, Zhu, Dali, Zheng, Jiecheng, Wu, Yue, Yu, Yu, Gan, Zongjie
Format Journal Article
LanguageEnglish
Published Philadelphia Taylor & Francis 03.04.2022
Taylor & Francis Ltd
Subjects
2-Aminobenzimidazoles and 2-aminobenzoxazoles
Aminobenzimidazole
Aminophenol
Cu(OAc)
desulfurization
Heterocyclic compounds
Synthesis
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Summary:An efficient and facile synthesis for 2-aminobenzimidazoles and 2-aminobenzoxazoles has been reported. Thioureas prepared from the reaction of o-phenylenediamines or 2-aminophenols and isothiocyanate derivatives, underwent desulfurization reaction smoothly under mild conditions in the presence of Cu(OAc) 2 , and afforded a variety of N-heterocyclic compounds in moderate to good yields.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2022.2065509