Sulfated iota-carrageenan from marine alga Agardhiella ramosissima prevents gastric injury in rodents via its antioxidant properties

• Published in: Algal research (Amsterdam) Vol. 77; p. 103371
• Main Authors: Pinheiro, João Lucas Silva, Rodrigues, Lucas Henrique Marques, Silva, Lorena Duarte da, Santos, Victória Martins Rodrigues dos, Gomes, Dayane Aparecida, Chagas, Francisco Diego da Silva, Chaves, Luciano de Sousa, Melo, Márcia Rúbia Silva, Freitas, Ana Lúcia Ponte, Souza, Marcellus Henrique Loiola Ponte, Medeiros, Jand-Venes Rolim, Damasceno, Renan Oliveira Silva
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.01.2024
• Subjects: Agardhiella ramosissima; Antioxidant; Gastric injury; Oxidative stress; Sulfated polysaccharide; Oxidative stress; GC–MS; Gastric injury; Sulfated polysaccharide; PPI; Agardhiella ramosissima; MDA; Antioxidant; NP-SH; NMR; NSAIDs; ROS; H2RA
• ISSN: 2211-9264; 2211-9264
• DOI: 10.1016/j.algal.2023.103371

In the present study, the gastroprotective effect of a sulfated polysaccharide isolated from marine alga Agardhiella ramosissima (SP-Ar) was investigated against alcoholic gastropathy. Gastric physiological functions and in vitro antioxidant activity also were studied. It was found that SP-Ar significantly reduced macroscopic injury and histologically maintained the architecture of gastric epithelium altered by ethanol, with maximum effect at 90 mg/kg. Importantly, animals treated with SP-Ar also had preservation of oxidative status, with reduction of nonprotein sulfhydryl groups (NP-SH) consumption and malondialdehyde (MDA) production, reduced vascular permeability, besides preventing gastric hemorrhage. In addition, SP-Ar administration did not modify gastric secretion or emptying. In vitro antioxidant data showed that SP-Ar presented high total antioxidant activity, DPPH radical scavenging, and ferrous iron chelating capacity. It was observed that SP-Ar protected gastric mucosa against alcoholic gastropathy by preventing the formation or neutralizing free radicals, associated with its intrinsic antioxidant activity. In this regard, this macromolecule should have possible application as a new therapeutic alternative or food additive to increase gastric mucosa defense. [Display omitted] •Sulfated iota-carrageenan from Agardhiella ramosissima (SP-Ar) reduces ethanol-induced gastric injury.•SP-Ar preserves the balance in the oxidative status in the ethanol-induced gastric injury.•SP-Ar does not modify gastric secretion or emptying.•SP-Ar has in vitro antioxidant activity.