Vaccination of Experimental Monkeys Against Plasmodium falciparum: A Possible Safe Adjuvant

Owl monkeys (Aotus trivirgatus griseimembra) were effectively immunized against a human malaria parasite, Plasmodium falciparum. Two injections of antigen, primarily mature segmenters with fully developed merozoites, mixed with adjuvant (6-O-stearoyl-N-acetylmuramyl-L-alanyl-D-isoglutamine and lipos...

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Published inScience (American Association for the Advancement of Science) Vol. 201; no. 4362; pp. 1237 - 1239
Main Authors Siddiqui, Wasim A., Taylor, Diane W., Kan, Siu-Chow, Kramer, Kenton, Richmond-Crum, Suzanne M., Kotani, Shozo, Shiba, Tetsuo, Kusumoto, Shoichi
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 29.09.1978
Subjects
Acetylmuramyl-Alanyl-Isoglutamine - immunology
Adjuvants, Immunologic
Animals
Antigens
Arm
Behavioral changes
Glycopeptides - immunology
Haplorhini
Infections
Liposomes
Malaria - prevention & control
Mental stimulation
Monkeys
Parasites
Plasmodium falciparum - immunology
Rotation
Vaccination
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Summary:Owl monkeys (Aotus trivirgatus griseimembra) were effectively immunized against a human malaria parasite, Plasmodium falciparum. Two injections of antigen, primarily mature segmenters with fully developed merozoites, mixed with adjuvant (6-O-stearoyl-N-acetylmuramyl-L-alanyl-D-isoglutamine and liposomes) were administered intramuscularly at a 4-week interval. Approximately 2 weeks after the second vaccination, the monkeys were challenged with the homologous strain of P. falciparum. All immunized monkeys survived the challenge. The substitution of Freund's complete adjuvant is an encouraging step toward the development of an effective and safe vaccine for human malaria.
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.99814