Association between type 2 diabetes mellitus and the evolution of endodontic pathology

• Published in: Quintessence international (Berlin, Germany : 1985) Vol. 51; no. 2; p. 100
• Main Authors: Ríos-Osorio, Néstor, Muñoz-Alvear, Hernan Darío, Montoya Cañón, Santiago, Restrepo-Mendez, Silvia, Aguilera-Rojas, Sandra E, Jiménez-Peña, Oscar, García-Perdomo, Herney Andrés
• Format: Journal Article
• Language: English
• Published: Germany 2020
• Subjects: Cross-Sectional Studies; Diabetes Mellitus, Type 2; Humans; Longitudinal Studies; Periapical Diseases; Root Canal Therapy; endodontics; dental pulp; periapical pathology; systematic review; diabetes
• ISSN: 1936-7163
• DOI: 10.3290/j.qi.a43865

The purpose of the present study was to assess the influence of type 2 diabetes mellitus (DM) on the evolution of pulpal and periapical pathology. Two reviewers independently conducted a systematic search for articles published between 1 January 2001 and 31 December 2018 on MEDLINE/PubMed, ISI Web of Science, and Scopus databases. An additional manual search was also carried out. Ten studies fulfilling the inclusion criteria were included in the review (two longitudinal studies with 1-year follow-up comparing the success of primary root canal treatment between type 2 diabetic patients and non-diabetic patients, and eight cross-sectional studies). Analysis of the ten studies showed that inadequate control of type 2 DM may predispose and influence the inflammatory pulpal and periapical disease evolution. The present systematic review suggests that there are biologic bases to suggest that type 2 DM may act as a risk factor for developing an endodontic pathology, affecting the course of the disease in terms of susceptibility, prevalence, progression, and tissue healing capacity as a consequence of a disrupted immune response. However, more well-designed clinical investigations carrying out suitable research methodologies are needed to elucidate the influence of type 2 DM on the pulpal and periapical disease evolution.