Cranberry juice decreases oxidative stress and improves glucose metabolism in patients with rheumatoid arthritis supplemented with fish oil

• Published in: PharmaNutrition Vol. 24; p. 100341
• Main Authors: Rosa, Flávia Troncon, de Souza Fatel, Elis Carolina, Alfieri, Daniela Frizon, Flauzino, Tamires, Scavuzzi, Bruna Miglioranza, Lozovoy, Marcell Alysson Batisti, Iriyoda, Tatiana Mayumi Veiga, Simão, Andréa Name Colado, Dichi, Isaias
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.06.2023
• Subjects: Carbohydrate metabolism; Lipid oxidation; N-3 polyunsaturated fatty acids; Polyphenols; Protein oxidation; Rheumatoid arthritis; T2DM; C; FO; TRAP; WC; N-3 polyunsaturated fatty acids; CL-LOOH; HDL; MEIA; LDL; NOx; VLDL; Polyphenols; FOCR; ACR/EULAR; T0; BMI; ORAC; DAS28; GH; DTNB; GLUT; Carbohydrate metabolism; EDTA; RA; TC; AOPP; HOMA-IR; TE; MetS; Protein oxidation; Rheumatoid arthritis; Lipid oxidation; TAG; PUFAs
• ISSN: 2213-4344; 2213-4344
• DOI: 10.1016/j.phanu.2023.100341

Beneficial effects of fish oil n-3 polyunsaturated fatty acids (PUFAs) have been reported in rheumatoid arthritis (RA), however, high doses of n-3 fatty acids have been associated with increased total and LDL cholesterol and impaired glucose metabolism. Cranberry products have been reported to improve markers of oxidative stress, inflammation, and the metabolic profile in patients with type 2 diabetes mellitus and with metabolic syndrome. We hypothesized that including low-energy cranberry juice on a regimen of fish oil supplementation could improve oxidative stress and attenuate the undesirable effects of fish oil in lipid and glucose metabolism in patients with RA. A 90-days randomized controlled trial was conducted. Patients (n = 70) were assigned to one of three groups: control (C); fish oil (FO) received 3 g of fish oil PUFAs supplementation/day; and fish oil and cranberry (FOCR) received 3 g of fish oil PUFAs and 500 mL of cranberry juice/day. There was no difference in parameters between FO and the C. FOCR group showed decreased glucose (p = 0.0225), lipid (p = 0.0079), protein (p = 0.0063) oxidation, and Oxidative Stress Index (p = 0.0375) values compared to FO. FOCR reduced glucose values (p = 0.0104), triacylglycerol (p = 0.0065), protein oxidation (p = 0.0042) and Oxidative Stress Index (OSI) (p = 0.0053) compared to the C. Compared to baseline, FO group decreased triacylglycerol (p = 0.0374) and increased glucose (p 0.0001), whereas FOCR group decreased triacylglycerol (p = 0.0398) values. 500 mL/day of reduced-calorie cranberry juice in patients with RA using fish oil supplementation decreased lipid, protein oxidation and OSI. [Display omitted] •Cranberry juice reduced glucose levels in rheumatoid arthritis (RA) patients supplemented with fish oil.•Cranberry juice with fish oil supplementation reduced triacylglycerol in patients with RA.•Cranberry juice decreased lipid oxidation in patients with RA supplemented with fish oil.•Cranberry juice decreased protein oxidation in patients with RA supplemented with fish oil.•Cranberry juice may prevent detrimental effects of high doses of fish oil on glucose metabolism in patients with RA.