Use of global sagittal flexibility to predict proximal junctional kyphosis after spinal deformity surgery

• Published in: Journal of neurosurgery. Spine Vol. 40; no. 1; p. 99
• Main Authors: Eaton, Ryan G, Wang, Joshua L, Munjal, Vikas, Dhaliwal, Joravar, Maggio, Dominic, Keister, Alexander, Gibbs, David, Mallory, Noah, Sparks, Alexander, Moranville, Robert, Xu, David S, Grossbach, Andrew J, Viljoen, Stephanus
• Format: Journal Article
• Language: English
• Published: United States 01.01.2024
• Subjects: Adult; Humans; Incidence; Kyphosis - complications; Kyphosis - diagnostic imaging; Kyphosis - surgery; Neurosurgical Procedures - adverse effects; Postoperative Complications - diagnostic imaging; Postoperative Complications - epidemiology; Postoperative Complications - etiology; Retrospective Studies; Spinal Fusion - adverse effects; Thoracic Vertebrae - diagnostic imaging; Thoracic Vertebrae - surgery; spinal deformity; global flexibility; global sagittal alignment; proximal junctional kyphosis
• ISSN: 1547-5646
• DOI: 10.3171/2023.8.SPINE23314

Sagittal alignment is an important predictor of functional outcomes after surgery for adult spinal deformity (ASD). A rigid spinal column may create a large lever arm that may impact the rate of proximal junctional kyphosis (PJK) after ASD surgery. In this study, the authors sought to determine whether relatively low preoperative global spinal flexibility (i.e., rigid spine) predicts increased incidence of PJK at 1 year after ASD surgery. The authors retrospectively reviewed long-segment thoracolumbar fusions with pelvic fixation performed at a single tertiary care center between October 2015 and September 2020 in patients with a minimum of 1-year radiographic and clinical follow-up. Two cohorts were established on the basis of the optimal value for spinal flexibility, as defined by the absolute difference between the preoperative standing and supine C7 sagittal vertical axes, which the authors termed global sagittal flexibility (GSF). Demographic information, radiographs, various associated complications, and patient-reported outcome measures (PROMs) were analyzed. Eighty-five patients met the inclusion criteria. Receiver operating characteristic (ROC) analysis using GSF to predict an increase in the proximal junctional sagittal Cobb angle (PJCA) greater than or equal to 10° at 1-year follow-up provided an area under the curve of 0.64 and identified an optimal GSF threshold value of 3.7 cm. Patients with GSF > 3.7 cm were considered globally flexible (48 patients), and those with GSF ≤ 3.7 cm were classified as rigid (37 patients). Rigid patients were noted to have a significantly higher risk of ΔPJCA ≥ 10° at 1-year follow-up (51.4% vs 29.3%, p = 0.049). No changes in the reoperation rates or PROMs based on GSF were observed in the 1- or 2-year postoperative window. Based on these retrospective data, preoperative global spinal rigidity portends an independently elevated risk for the development of PJK after ASD surgery. No differences in other complication rates or PROMs data were observed between groups. Data collection was limited to a 2-year postoperative window; therefore, longer follow-up is required to further elucidate the relationship between rigidity and reoperation rates. Based on these retrospective data, flexibility may influence the outcomes of patients with ASD.