Localization of messenger RNAs encoding enzymes associated with malonyl-CoA metabolism in mouse brain

• Published in: Gene Expression Patterns Vol. 1; no. 3; pp. 167 - 173
• Main Authors: Sorensen, Annette, Travers, Maureen T, Vernon, Richard G, Price, Nigel T, Barber, Michael C
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.10.2002
• Subjects: Acetyl-CoA carboxylase; Carnitine palmitoyltransferase I; Distribution; Fatty acid synthase; In situ hybridization; Malonyl-CoA decarboxylase; Acetyl-CoA carboxylase; Carnitine palmitoyltransferase I; Distribution; Cellular and molecular biology; Malonyl-CoA decarboxylase; Fatty acid synthase; In situ hybridization
• ISSN: 1567-133X; 1872-7298
• DOI: 10.1016/S1567-133X(02)00013-3

Malonyl-CoA acts a fuel sensor in the pancreas, liver and muscle. Similarly, malonyl-CoA is implicated in satiety regulation in the brain. Expression of genes encoding enzymes implicated in regulation of malonyl-CoA levels was examined in murine brain. Acetyl-CoA carboxylase (ACC) α-isoform, fatty acid synthase and malonyl-CoA decarboxylase are highly expressed in the hippocampus, habenula nucleus, cerebral cortex and areas of the hypothalamus, whereas the ACC-β isoform and liver-type carnitine palmitoyltransferase I (CPT I-L) are principally expressed in the choroid plexus. Thus different brain regions appear to be functionally configured primarily for either fatty acid synthesis or β-oxidation. Localization of transcripts encoding enzymes involved in fatty acid synthesis and β-oxidation in distinct nuclei of the hypothalamus supports a role for malonyl-CoA as a potential effector of satiety.