Regulation of chemokine receptor CCR5 and production of RANTES and MIP-1α by interferon-β

• Published in: Journal of neuroimmunology Vol. 112; no. 1; pp. 174 - 180
• Main Authors: Zang, Ying C.Q., Halder, Jyotsnabaran B., Samanta, Ajoy K., Hong, Jian, Rivera, Victor M., Zhang, Jingwu Z.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 2001
• Subjects: b-Interferon; CCR5; CCR5 protein; Chemokines; Cytokines; Interferon-β; macrophage inflammatory protein 1^a; macrophage inflammatory protein 1a; Multiple sclerosis; RANTES; Interferon-β; Multiple sclerosis; Cytokines; CCR5; Chemokines
• ISSN: 0165-5728; 1872-8421
• DOI: 10.1016/S0165-5728(00)00397-0

Trafficking of inflammatory T cells into the brain is associated with interactions of certain chemokines with their receptors, which plays an important role in the pathogenesis of multiple sclerosis (MS). We examined whether interferon-β (IFN-β) had the ability to regulate the production of chemokines and the expression of their receptors in T cells derived from patients with MS. It was demonstrated for the first time that in vitro exposure of T cells to IFN-β-1a selectively inhibited mRNA expression for RANTES and MIP-1α and their receptor CCR5. T cell surface expression of CCR5 was significantly reduced in MS patients treated with IFN-β, correlating with decreased T cell transmigration toward RANTES and MIP-1α. The study provides new evidence suggesting that IFN-β treatment impairs chemokine-induced T cell trafficking by reducing the production of RANTES and MIP-1α and the expression of their receptors CCR5.