Acute peripheral neuropathy following animal envenomation: A case report and systematic review

• Published in: Journal of the neurological sciences Vol. 442; p. 120448
• Main Authors: Mathis, Stéphane, Carla, Louis, Duval, Fanny, Nadal, Louis, Solé, Guilhem, Le Masson, Gwendal
• Format: Journal Article
• Language: English
• Published: Netherlands 15.11.2022
• Subjects: Animals; Humans; Male; Middle Aged; Peripheral Nervous System Diseases - etiology; Phospholipases; Vasculitis - complications; Acute peripheral neuropathy; Mononeuropathy; Allergy; Guillain–Barré syndrome; Phospholipase-A2; Venom
• ISSN: 0022-510X; 1878-5883
• DOI: 10.1016/j.jns.2022.120448

Animal envenomation in humans is usually accidental or for defensive purposes. Depending on the venom composition and administration, different reactions can be observed. After reporting the first case of acute polyradiculitis in a 57-year-old healthy male after red lionfish envenomation, we propose to analyze rare similar cases of acute neuritis after animal envenomation published in the medical literature. Including our case, we found 54 patients who developed acute peripheral neuropathy after having been stung or bitten by various animals, mainly hymenoptera (in half of the cases) but also jellyfishes, snakes, corals or nonhooked arthropods. We observed two distinct patterns of peripheral neuropathy: more than half of them were polyneuropathy while the others were focal neuropathy. The prognosis was favorable in most cases. The pathophysiological mechanism associated with these rare complications remain unknown, although some hypotheses may be proposed. A direct action of certain components of the venom, such as phospholipase-A2, could explain the focal forms of peripheral neuropathy trough toxic reactions and/or vasculitis processes. The more diffuse clinical situations could be due to an allergy-triggered immune-mediated reaction (possibly linked to a molecular mimicry mechanism between venom proteins and some myelin proteins of the peripheral nervous system), or to the action of some venom components on membrane ionic channels particularly at the node of Ranvier. Even if acute peripheral neuropathies are rare after envenomation, they may occur after envenomation from various animals, and their usually favorable prognoses should be known by neurologists.