Stable enhancement of tissue-type plasminogen activator levels in blood: Interrupted chamber hypoxia mimics effects of alpine hypoxia

The influence of native mountain, artificial acute and interrupted prolonged barochamber hypoxia on the tissue-type plasminogen activator (t-PA) level in blood and tissues was studied in Wistar rats. All types of hypoxia induced an elevation of blood t-PA activity due to a stimulatory effect on the...

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Bibliographic Details
Published inFibrinolysis Vol. 8; pp. 80 - 81
Main Authors Bashkov, G.V., Miftachova, N.T., Sergeev, I.Y., Koshelev, V.B., Makarov, V.A.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 1994
Subjects
Hypoxia
Mountain Hypoxia
Tissue-type plasminogen activator
Mountain Hypoxia
Hypoxia
Tissue-type plasminogen activator
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Summary:The influence of native mountain, artificial acute and interrupted prolonged barochamber hypoxia on the tissue-type plasminogen activator (t-PA) level in blood and tissues was studied in Wistar rats. All types of hypoxia induced an elevation of blood t-PA activity due to a stimulatory effect on the lung vascular endothelium. In contrast to acute barochamber hypoxia a middle-term adaptation to the hypoxic circumstances caused a stable enhancement of blood t-PA activity. The acute barochamber hypoxia by an unknown pathway stimulated only the release of t-PA, but the long-lasting hypoxia caused both the secretion and synthesis of t-PA de novo.
ISSN:0268-9499
DOI:10.1016/0268-9499(94)90254-2