Effects of exogenous porcine somatotropin on the carcass composition, hormonal and metabolic profiles, lipogenic capacity, and binding of insulin to erythrocyte receptors of fast- versus slow-growing swine

• Published in: Journal of animal science Vol. 71; no. 7; p. 1786
• Main Authors: Mikel, W.B, Althen, T.G, Rogers, R.W, Moore, A.B, Miller, H.W, Miller, L.F
• Format: Journal Article
• Language: English
• Published: United States 01.07.1993
• Subjects: Adipose Tissue - drug effects; Adipose Tissue - growth & development; ANALISIS ORGANOLEPTICO; ANALYSE ORGANOLEPTIQUE; Animals; Blood Glucose - analysis; Blood Urea Nitrogen; Body Composition - drug effects; CERDO; COMPOSICION DE LA CANAL; COMPOSITION DE LA CARCASSE; DESEMPENO; ENGORDE; ENGRAISSEMENT; Erythrocytes - metabolism; Fatty Acids, Nonesterified - blood; GAIN DE POIDS; GANANCIA DE PESO; Growth Hormone - blood; Growth Hormone - pharmacology; Hormones - blood; INDICE DE CRECIMIENTO; Insulin - blood; Insulin - metabolism; Insulin-Like Growth Factor I - analysis; INSULINA; INSULINE; Lipids - biosynthesis; Male; Meat - standards; METABOLITE; METABOLITOS; Muscle Development; Muscles - drug effects; PORCIN; Random Allocation; RECEPTEUR D'HORMONE; Receptor, Insulin - metabolism; RECEPTORES DE HORMONAS; SERUM SANGUIN; SOMATOTROPINA; SOMATOTROPINE; SUERO SANGUINEO; Swine - growth & development; Swine - metabolism; TAUX DE CROISSANCE; Weight Gain - drug effects
• ISSN: 0021-8812; 1525-3163
• DOI: 10.2527/1993.7171786x

Twenty barrows were designated as fast-growing (FG) and their littermates designated as slow-growing (SG) based on birth, weaning, and 56-d weight. Half of each group received 70 micrograms of porcine somatotropin (pST)/kg BW daily beginning at 40 kg BW. At 60 and 105 kg BW, blood was collected every 0.5 h for 12 h beginning 1 h before pST injection, fat biopsies were taken for in vitro lipogenic activity, and insulin erythrocytes were isolated for receptor binding. Swine treated with pST had elevated ADG (.95 vs 0.88 kg/d; P 0.1) and reduced days to slaughter (61 vs 67; P 0.1). The pst-treated pigs had less average backfat (2.73 vs 3.96 cm; P 0.01), larger longissimus muscle areas (32.3 vs 28.2 cm2; P 0.05), and a higher percentage of muscle (56.3 vs 50.3%; P 0.01) than control pigs. Exogenous pST increased protein (17.4 vs 13.2%; P 0.05) and decreased fat (22.9 vs 37.1%; P .05). The FG pigs had higher ADG (.98 vs 0.86 kg/d; P 0.01) and required fewer days to slaughter (57 vs 71; P 0.01) than SG pigs. Administration of pST increased (P 0.01) average pST levels (1.7 vs 14.0 ng/mL) in FG and SG pigs at 60 kg BW. At 105 kg BW, pST was higher (P 0.01) in pST-FG than in pST-SG swine (46.0 vs 19.3 ng/mL) but was not different between FG and SG control swine (1.9 vs 1.8 ng/mL). Administration of PST increased concentrations of IGF-I (510.0 vs 160.0 ng/mL) and nonesterified fatty acids (182 vs 109 microEq/L, P 0.01) in FG and SG swine. Over sample periods and growth rates, pST reduced (P 0.05) CO2 production and lipid synthesis (.345 and 1.85 vs 0.575 and 2.71 micromoles of glucose incorporated.g-1.2 h-1). At 60 kg BW, FG swine had less (P 0.01) CO2 production and lipid synthesis (.299 and 1.83 vs 0.921 and 3.61 micromoles.g-1.2 h-1) than did SG swine. Exogenous pST increased (P 0.05) binding to insulin erythrocyte receptors (7.25 vs 6.34%)