Adsorption of rhG-CSF to Various Intravenous Filters

• Published in: Byōin yakugaku Vol. 22; no. 4; pp. 359 - 363
• Main Authors: YAGO, KAZUO, MATSUBARA, HAJIME, SAKUMA, MASAHIKO, OTORI, KATSUYA, SHIMADA, SHIGEHIKO
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Pharmaceutical Health Care and Sciences 1996
• Subjects: adsorption; cytokines; intravenous filter; rhG-CSF
• ISSN: 0389-9098; 2185-9477
• DOI: 10.5649/jjphcs1975.22.359

With a recent progress in biotechnology, mass production of various kinds of cytokines became possible. At present, recombinant human granulocyte-colony stimulating factor, rhG-CFG is widely applied to clinical areas, and its good efficacy has been confirmed. rhG-CSF is administered by drip infusion or by subcutaneous injection, which is chosen depending on the indications. We previously indicated that the adsorption of rhG-CSF onto an end-line filter used for preventing compromised hosts from the infection or the infusion route was a serious problem for its use, because the administration dose was extremely low, in an order of μg. Since we obtaind a newly developed filter (PDl), we made a comparative study on the adsorption of rhG-CSF to two kinds of filters which are frequently used for infusion; ELD-096LL and IVEX-II.The drug was used at a half of the ordinary adult dose of 150μg/100ml. The adsorption of rhG-CSF was found for the conventional filters but almost not for the new fluter tested. Its adsorption to the infusion route was estimated to be 10-20%.