Correlation of β-catenin, but not PIN1 and cyclin D1, overexpression with disease-free and overall survival in patients with cancer of the parotid gland

• Published in: Head & neck Vol. 37; no. 1; pp. 30 - 36
• Main Authors: Lill, Claudia, Schneider, Sven, Seemann, Rudolf, Kadletz, Lorenz, Aumayr, Klaus, Ghanim, Bahil, Thurnher, Dietmar
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.01.2015
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; beta Catenin - metabolism; Carcinoma - metabolism; Carcinoma - mortality; Carcinoma - pathology; Cyclin D1; Cyclin D1 - metabolism; Disease-Free Survival; Female; Humans; Male; Middle Aged; NIMA-Interacting Peptidylprolyl Isomerase; parotid cancer; Parotid Neoplasms - metabolism; Parotid Neoplasms - mortality; Parotid Neoplasms - pathology; Peptidylprolyl Isomerase - metabolism; PIN1; Retrospective Studies; salivary gland cancer; Survival Rate; Young Adult; ß-catenin; PIN1; salivary gland cancer; ß-catenin; Cyclin D1; parotid cancer
• ISSN: 1043-3074; 1097-0347
• DOI: 10.1002/hed.23546

ABSTRACT Background Malignant tumors of the salivary glands comprise about 3% to 5% of all head and neck carcinomas. The purpose of our study was to find possible predictive and/or prognostic markers for parotid cancer. Methods A total of 46 tissue samples of carcinomas of the parotid gland were immunohistochemically stained for ß‐catenin, cyclin D1, and PIN1. The factors were analyzed regarding their prognostic value for disease‐free and overall survival. Results An overexpression of the cytoplasmatic ß‐catenin was linked to a statistically significant worse outcome regarding disease‐free (p = .0296) and overall survival (p = .0416). The 5‐year overall survival was 83.9% in patients without and 0% in patients presenting with overexpression of cytoplasmatic ß‐catenin. Additionally, Union Internationale Contre le Cancer (UICC) stage correlated with overall survival (p = .0306) and disease‐free survival (DFS; p = .0473). Conclusion Multivariate analysis showed that overexpression of cytoplasmatic ß‐catenin and the UICC stage are 2 independent prognostic markers for survival in patients with parotid cancer. © 2014 Wiley Periodicals, Inc. Head Neck 37: 30–36, 2015