A Study on Adsorption of Calcitonin Preparations on Syringes

• Published in: Byōin yakugaku Vol. 26; no. 3; pp. 273 - 279
• Main Authors: YAGO, KAZUO, KUROYAMA, MASAKAZU, OTORI, KATSUYA, HIRAYAMA, TAKESHI, OGAWA, YUKIO, AOTO, HIROYUKI
• Format: Journal Article
• Language: Japanese; English
• Published: Japanese Society of Pharmaceutical Health Care and Sciences 2000
• Subjects: adsorption on plastic syringes; calcitonin preparations; calcitonin preparations on syringe; elcatonin; salmon calcitonin
• ISSN: 0389-9098; 2185-9477
• DOI: 10.5649/jjphcs1975.26.273

The adsorption of marketed elcatonin (3 preparations) and salmon calcitonin (2 preparations) was examined. Each aqueous preparation in an ample was drawn into plastic syringes and then was stored still for 0, 1, 3, 5, 10, 30 or 60 min. The preparation was thereafter squeezed out of the syringe, and the remaining rate of elcatonin or salmon calcitonin in the solution was measured. In every elcatonin preparation, the remaining rate just after suction into the syringe was about 90%, and thereafter, the amount markedly decreased with time showing a rate of about 50% after 30 min. On the other hand, two salmon calcitoin preparations did not show any clear difference in these ratea. Namely, preparations containing gelatin as an ingredient showed a remaining rate of about 90% after up to 60 min of storage, and only a slight decrease was observed. In other preparations, the remaining rate at the point of suction into the syringe was about 90 %, but the rate thereafter decreased markedly to 50-60% affer 10 min. When administering elcatonin and salmon calcitonin preparations, sufficient attention should thus be paid to such adsorption in syringes. However, for elcatonin and salmon calcitonin preparations in syringes which do not require suctioning into the syringes, we found that the appropriate dose could be reliably administered.