Multiple subsets of regulatory T-cells

• Published in: Bi͡u︡lletenʹ Sibirskoĭ medit͡s︡iny Vol. 19; no. 3; pp. 144 - 155
• Main Authors: Kupriyanov, S. V., Sinitsky, A. I., Dolgushin, I. I.
• Format: Journal Article
• Language: English
• Published: Siberian State Medical University (Tomsk) 07.10.2020
• Subjects: treg памяти; иммунологическая толерантность; регуляторные т-лимфоциты; тканеспецифичные treg; эффекторные treg
• ISSN: 1682-0363; 1819-3684
• DOI: 10.20538/1682-0363-2020-3-144-155

Regulatory T-lymphocytes play a central role in the immunological tolerance system. To date, existence of many different subpopulations of regulatory T-cells have been described. However, a number of questions related to the function, differentiation, and homeostasis of these subpopulations in a body remain unclear. Interactions between the previously discovered pairs of helper and regulatory T-lymphocytes require further study. The main topic is identification and establishment of the functions of regulatory memory cells. Interstitial migration of activated regulatory T-lymphocytes is also a promising direction. In this review, we summarized the main findings in multiple subsets of regulatory T-lymphocytes, discussed unclear data that will require further studies, and  showed an application for regulatory T-lymphocytes in medicine.