Methemoglobinemia due to nitric oxide therapy in a child after cardiac surgery

A 5-month-old boy with trisomy 21 had repair of ventricular septal defect, atrial septal defect, and ligation of a patent ductus arteriosus. Due to severe pulmonary hypertension, NO inhalation was instituted postoperatively. Over the course of next few hours, he developed life-threatening methemoglo...

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Bibliographic Details
Published inAsian cardiovascular & thoracic annals Vol. 21; no. 3; pp. 345 - 347
Main Authors Syed, Aitizaz Uddin, Jelly, Ali E Ali, Algebaly, Ahmed Azmy, Altoonisi, Mustafa M, Shatoory, Ahmed El
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.06.2013
Subjects
Abnormalities, Multiple
Administration, Inhalation
Antihypertensive Agents - administration & dosage
Antihypertensive Agents - adverse effects
Blood Transfusion
Cardiac Surgical Procedures
Familial Primary Pulmonary Hypertension
Heart Defects, Congenital - complications
Heart Defects, Congenital - diagnosis
Heart Defects, Congenital - surgery
Humans
Hypertension, Pulmonary - diagnosis
Hypertension, Pulmonary - drug therapy
Hypertension, Pulmonary - etiology
Infant
Male
Methemoglobinemia - chemically induced
Methemoglobinemia - diagnosis
Methemoglobinemia - therapy
Nitric Oxide - administration & dosage
Nitric Oxide - adverse effects
Time Factors
Treatment Outcome
Heart defects
nitric oxide
congenital
infant
methemoglobinemia
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Summary:A 5-month-old boy with trisomy 21 had repair of ventricular septal defect, atrial septal defect, and ligation of a patent ductus arteriosus. Due to severe pulmonary hypertension, NO inhalation was instituted postoperatively. Over the course of next few hours, he developed life-threatening methemoglobinemia. The condition once recognized was corrected with exchange blood transfusion. The management strategy is described with a brief review of the literature.
Bibliography:ObjectType-Case Study-3
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Review-1
ObjectType-Feature-5
ObjectType-Report-2
ObjectType-Article-4
ISSN:0218-4923
1816-5370
DOI:10.1177/0218492312454276