γ-Glutamyltranspeptidase and pH based "AND" logic gate fluorescent probe for orthotopic breast tumor imaging

An "AND" logic gate-based NIR fluorescent probe Si-NH 2 -Glu was developed based on novel meso -amine Si-Rhodamine, which combined γ-glutamyl transpeptidase and pH dual-responsive sites. The features of Si-NH 2 -Glu enable it to be applied in orthotopic tumor imaging and fluorescence-guide...

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Published inChemical communications (Cambridge, England) Vol. 59; no. 19; pp. 2795 - 2798
Main Authors Zhang, Li-Na, Zhang, Hong, Chen, Shan-Yong, Liu, Yan-Zhao, Yang, Xiao-Hua, Xiang, Fei-Fan, Liu, Yan-Hong, Li, Kun, Yu, Xiao-Qi
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 02.03.2023
Subjects
Breast Neoplasms
Female
Fluorescent Dyes
Fluorescent indicators
gamma-Glutamyltransferase
Humans
Hydrogen-Ion Concentration
Logic circuits
Optical Imaging - methods
Rhodamine
Tumors
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Summary:An "AND" logic gate-based NIR fluorescent probe Si-NH 2 -Glu was developed based on novel meso -amine Si-Rhodamine, which combined γ-glutamyl transpeptidase and pH dual-responsive sites. The features of Si-NH 2 -Glu enable it to be applied in orthotopic tumor imaging and fluorescence-guided surgery. Combining γ-glutamyl transpeptidase and pH dual-responsive sites, an "and" logic gate-based NIR fluorescent probe Si-NH 2 -Glu was developed for orthotopic breast tumor imaging.
Bibliography:https://doi.org/10.1039/d2cc06568a
Electronic supplementary information (ESI) available. See DOI
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SourceType-Scholarly Journals-1
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d2cc06568a