Surface-regulated injection dose response of ultrasmall luminescent gold nanoparticles
With the rapid growth of the use of renal-clearable nanomedicines in disease targeting and therapy, a fundamental understanding of their injection dose responses is of great importance for future translation to clinical settings. Using glutathione-coated gold nanoparticles (GS-AuNPs) as a renal-clea...
Saved in:
Published in | Nanoscale Vol. 14; no. 24; pp. 8818 - 8824 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
Royal Society of Chemistry
23.06.2022
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | With the rapid growth of the use of renal-clearable nanomedicines in disease targeting and therapy, a fundamental understanding of their injection dose responses is of great importance for future translation to clinical settings. Using glutathione-coated gold nanoparticles (GS-AuNPs) as a renal-clearable nanomedicine model for the construction of ultrasmall AuNPs with different serum protein binding abilities, we discover that the concentration-dependent serum protein binding capabilities endow GS-AuNPs with a more sensitive response to injection dose than NPs resistant to serum protein binding, resulting in greatly improved tumor-targeting efficiencies during both single and repeated low-dose injections; the performance is also distinct from nonrenal-clearable AuNPs coated with serum protein, which show decreased tumor-targeting efficiency with a decrease in the injection dose.
Concentration-dependent serum protein binding capabilities endow renal-clearable AuNPs with a more sensitive response to injection dose than those resistant to serum protein binding, resulting in dose-dependent tumor-targeting efficiencies. |
---|---|
Bibliography: | https://doi.org/10.1039/d2nr01784a Electronic supplementary information (ESI) available. See DOI ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2040-3364 2040-3372 |
DOI: | 10.1039/d2nr01784a |