Increased frequency of CD14+HLA-DR-/low cells in type 2 diabetes patients with poor glycemic control

• Published in: Human immunology Vol. 83; no. 11; pp. 789 - 795
• Main Authors: Valtierra-Alvarado, M.A., Castañeda-Delgado, J.E., Lugo-Villarino, G., Dueñas-Arteaga, F., Rivas-Santiago, B., Enciso-Moreno, J.A., Serrano, C.J.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.11.2022; Elsevier
• Subjects: Adaptive immunology; Diabetes; Endocrinology and metabolism; Glycemic control; Human health and pathology; Immunology; Immunosuppression; Life Sciences; MDSCs; Monocytes; Glycemic control; MDSCs; Monocytes; Immunosuppression; Diabetes
• ISSN: 0198-8859; 1879-1166
• DOI: 10.1016/j.humimm.2022.08.011

Type 2 diabetes (T2DM) is associated with alterations of the immune response and T2DM patients have an increased risk for infections and certain sorts of cancers. Although CD14+HLA-DR-/low cells have emerged as important mediators of immunosuppression in several pathologies, including cancer and non-malignant diseases, the presence of these cells in T2DM is not fully characterized. In this study, we evaluated the frequency of CD14+HLA-DR-/low cells in non-obese T2DM patients and their association with glycemic control. Peripheral blood mononuclear cells were isolated from healthy controls (HC, n = 24) and non-obese T2DM patients (n = 25), the population was evaluated by flow cytometry, and an analysis of correlation between cell frequencies and clinical variables was performed. CD14+HLA-DR-/low monocytes were expanded in patients with T2DM compared to HC regardless of weight. Among the subjects with T2DM, the frequency of CD14+HLA-DR-/low was higher in patients with poor glycemic control (HbA1c > 9%) compared to those with better glycemic control (HbA1c < 9%) and, positively correlated with the years since the diagnosis of T2DM, the age of the patients and the glycemic index. An increased frequency of CD14+HLA-DR-/low cells in the blood of T2DM patients was recorded. The influence of hyperglycemia seems to be independent of obesity, but related to glycemic control and age.