Erythropoietin Nanobots: Their Feasibility for the Controlled Release of Erythropoietin and Their Neuroprotective Bioequivalence in Central Nervous System Injury

• Published in: Applied sciences Vol. 12; no. 7; p. 3351
• Main Authors: Le, Thi Huong, Nguyen, Chanh Trung, Koo, Kyo-in, Hwang, Chang Ho
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.04.2022
• Subjects: Apoptosis; Bioequivalence; Blood diseases; Caspase-3; Cell activation; Cell viability; Central nervous system; Controlled release; Drying; Endoplasmic reticulum; Erythropoietin; Feasibility; Injury prevention; Janus kinase 2; Nanoparticles; Nervous system; Neuroprotection; Phylogeny; Polymers; Preconditioning; Receptor mechanisms; regeneration; Sonication; Thapsigargin; therapeutics; Ultrasonic imaging; St Louis Missouri; United States > US

Background: Erythropoietin (EPO) plays important roles in neuroprotection in central nervous system injury. Due to the limited therapeutic time window and coexistence of hematopoietic/extrahematopoietic receptors displaying heterogenic and phylogenetic differences, fast, targeted delivery agents, su...