Alterations in Serum Lead Levels Following Packed Red Blood Cells Transfusions to Preterms Admitted to Neonatal Intensive Care Unit at Cairo University Pediatric Hospital

Background: The study aimed to evaluate the direct effects of packed red blood cells (PRBCs) transfusions on neonatal blood lead levels (BLL) among the neonates admitted to Cairo University Pediatric Hospital (CUPH). Methods: It is a prospective cohort study including fifty-four premature neonates w...

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Published inMajallah-ʼi bīmārīhā-yi kūdakān-i Īrān = Iranian journal of pediatrics Vol. 29; no. 4
Main Authors Abd El Fatah, Shaimaa A. M., Labib, John Rene, Gomaa, Nancy A. S., Ibrahem, Sally Kamal, Soliman Attia, Mona Adel
Format Journal Article
LanguageEnglish
Published Tehran Tehran University of Medical Sciences 01.08.2019
Subjects
Age
Anemia
Birth weight
Blood
Intensive care
Laboratories
Lead content
Lead poisoning
Mortality
Newborn babies
Nutrition
Pediatrics
Premature birth
Sepsis
Variables
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Summary:Background: The study aimed to evaluate the direct effects of packed red blood cells (PRBCs) transfusions on neonatal blood lead levels (BLL) among the neonates admitted to Cairo University Pediatric Hospital (CUPH). Methods: It is a prospective cohort study including fifty-four premature neonates which took place over a period of 6 months starting from January 2018. Baseline and post-transfusion BLL were obtained. Neonatal BLL percent change was calculated to quantify the change levels before and after transfusion. Results: The neonatal BLL after transfusion was elevated one and half times more than that before transfusion. The median neonatal BLL% change was significantly higher in neonates diagnosed with extremely low birth weight and neonatal sepsis. BLL after transfusion showed a positive, moderate and significant relationship with neonatal weight, lead level in blood packs, gestational age, and blood creatinine level respectively. Multiple regression was used to explore the relationship between BLL% change and a number of predictors (e.g. neonatal age, weight, gestational age, number of transfusion times and lead level in blood packs). Conclusions: The study concluded that preterm neonates are at risk of lead exposure hazards due to receiving PRBCs transfusions. Higher lead levels in PRBCs denotes exposure of donors to higher lead levels and accordingly the recipient preterms.
ISSN:2008-2142
2008-2150
DOI:10.5812/ijp.90977