Spectrophotometric Determination of Nitroxoline in Medicines Using the Response Surface Methodology

It was shown by the conductometric study that the formation of micelles in the cetyltrimethylammonium bromide (CTAB) – dimethylsulfoxide (DMSO) – water system occurs at higher critical micelle concentrations (CMC) than in the CTAB – water system. The solubilization of nitroxoline in this system upon...

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Published inUchenye zapiski Kazanskogo universiteta. Serii͡a︡ Estestvennye nauki Vol. 165; no. 1
Main Authors R. F. Bakeeva, S. Yu. Garmonov, V. D. Osipova, K. V. Chernyj, S. Yu. Mamykina, V. F. Sopin
Format Journal Article
LanguageEnglish
Published Kazan Federal University 01.01.2023
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Summary:It was shown by the conductometric study that the formation of micelles in the cetyltrimethylammonium bromide (CTAB) – dimethylsulfoxide (DMSO) – water system occurs at higher critical micelle concentrations (CMC) than in the CTAB – water system. The solubilization of nitroxoline in this system upon reaching the CMC was determined by the spectrophotometric method. The Box–Behnken design was used to obtain systems with the highest light absorption of nitroxoline, depending on the CTAB concentration, the acidity of the pH medium, and the proportion of DMSO when searching for the optimal matrix. A sensitive and selective technique suitable for micellar media and spectrophotometric analysis was developed using the response surface methodology for the determination of nitroxoline in medicines.
ISSN:2542-064X
2500-218X
DOI:10.26907/2542-064X.2023.1.118-132