Analytical Problems Encountered with NIOSH Method 5521 for Total Isocyanates

A recent analysis for total isocyanates in air using National Institute for Occupational Safety and Health Method 5521 presented difficulties in the identification of an oligomeric isocyanate species. Two problems were encountered during the analysis. A false negative response in the high performanc...

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Bibliographic Details
Published inAmerican Industrial Hygiene Association journal Vol. 56; no. 5; pp. 474 - 479
Main Author Key-Schwartz, Rosa J.
Format Journal Article
LanguageEnglish
Published Fairfax, VA American Industrial Hygiene Association Journal 01.05.1995
American Industrial Hygiene Association
Taylor & Francis Ltd
Subjects
Air Pollutants, Occupational - analysis
Air pollution
Analysis methods
Applied sciences
Atmospheric pollution
Chromatography
Chromatography, High Pressure Liquid
Effectiveness
Exact sciences and technology
False Negative Reactions
Health hazards
Indoor pollution and occupational exposure
Isocyanates - analysis
Laboratories
National Institute for Occupational Safety and Health (U.S.)
Occupational safety
Pollution
Reagents
Regulation
Sensors
Sodium
Spectrum analysis
Studies
Test methods
United States
United States
United States > US
Isocyanates
Work place
Chemical analysis
HPLC chromatography
Air pollution
Oligomer
Ultraviolet spectrometry
Electrochemical detector
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Summary:A recent analysis for total isocyanates in air using National Institute for Occupational Safety and Health Method 5521 presented difficulties in the identification of an oligomeric isocyanate species. Two problems were encountered during the analysis. A false negative response in the high performance liquid chromatography chromatogram was encountered in a majority of the field samples. An anomalous peak served to give a false positive in some of the field blanks and in some of the field samples. Through supplementing the ratio criterion of Method 5521 using the complete UV absorption spectrum from a photodiode array (PDA) UV detector, the two peaks were successfully identified. However, this need for additional data to identify an oligomeric isocyanate species raises the question of whether the ratio criterion of Method 5521 allows the qualitative identification of isocyanate oligomers.
ISSN:0002-8894
2163-369X
DOI:10.1080/15428119591016890