p38MAPK : stress responses from molecular mechanisms to therapeutics

• Published in: Trends in molecular medicine Vol. 15; no. 8; pp. 369 - 379
• Main Authors: Coulthard, Lydia R, White, Danielle E, Jones, Dominic L, McDermott, Michael F, Burchill, Susan A
• Format: Journal Article
• Language: English
• Published: 01.08.2009
• Subjects: Pathology

The p38MAPK protein kinases affect a variety of intracellular responses, with well-recognized roles in inflammation, cell-cycle regulation, cell death, development, differentiation, senescence and tumorigenesis. In this review, we examine the regulatory and effector components of this pathway, focus...