p38MAPK : stress responses from molecular mechanisms to therapeutics

The p38MAPK protein kinases affect a variety of intracellular responses, with well-recognized roles in inflammation, cell-cycle regulation, cell death, development, differentiation, senescence and tumorigenesis. In this review, we examine the regulatory and effector components of this pathway, focus...

Full description

Saved in:
Bibliographic Details
Published inTrends in molecular medicine Vol. 15; no. 8; pp. 369 - 379
Main Authors Coulthard, Lydia R, White, Danielle E, Jones, Dominic L, McDermott, Michael F, Burchill, Susan A
Format Journal Article
LanguageEnglish
Published 01.08.2009
Subjects
Pathology
Online AccessGet full text

Cover

More Information
Summary:The p38MAPK protein kinases affect a variety of intracellular responses, with well-recognized roles in inflammation, cell-cycle regulation, cell death, development, differentiation, senescence and tumorigenesis. In this review, we examine the regulatory and effector components of this pathway, focusing on their emerging roles in biological processes involved in different pathologies. We summarize how this pathway has been exploited for the development of therapeutics and discuss the potential obstacles of targeting this promiscuous protein kinase pathway for the treatment of different diseases. Furthermore, we discuss how the p38MAPK pathway might be best exploited for the development of more effective therapeutics with minimal side effects in a range of specific disease settings.
Bibliography:Both authors contributed equally to this manuscript..
ISSN:1471-4914
1471-499X
DOI:10.1016/j.molmed.2009.06.005