Practical syntheses of B disaccharide and linear B type 2 trisaccharide-non-primate epitope markers recognized by human anti-alpha-Gal antibodies causing hyperacute rejection of xenotransplants

Synthetic protocols are presented for the elaboration of Gal alpha1 --> 3GalOR and Gal alpha1 --> 3Gal beta1 --> 4GlcNAcOR di- and trisaccharides that use a common Gal donor/acceptor unit, and are potentially adaptable to scale-up. (C) 2001 Elsevier Science Ltd. All rights reserved.

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Bibliographic Details
Published inTetrahedron Vol. 57; no. 16; pp. 3267 - 3280
Main Authors Hanessian, S, Saavedra, OM, Mascitti, Marterer, W, Oehrlein, R, Mak, CP
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 16.04.2001
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
PIGS
INHIBITION
ACID
glycoside synthesis
SPECIFICITY
GLYCOSIDASE-CATALYZED SYNTHESIS
oligosaccharides
new donors
GALACTOSYL EPITOPES
GLYCOSYLATION
FLUORIDES
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Summary:Synthetic protocols are presented for the elaboration of Gal alpha1 --> 3GalOR and Gal alpha1 --> 3Gal beta1 --> 4GlcNAcOR di- and trisaccharides that use a common Gal donor/acceptor unit, and are potentially adaptable to scale-up. (C) 2001 Elsevier Science Ltd. All rights reserved.
ISSN:0040-4020
DOI:10.1016/S0040-4020(01)00196-X