Antiarrhythmic properties of a new Suphan-based combined preparation and their possible mechanism of realisation

Considerable potentiation of antiarrhythmic and antifibrilation effects of two cardiotonic agents, Suphan and the Na-channel blocker L1, was found in the model experimentsin vivo with early occlusion and reperfusion arrhythmias. Suphan in combination with L1 inhibited the rise of intracellular Ca^su...

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Published inBulletin of experimental biology and medicine Vol. 125; no. 1; pp. 50 - 52
Main Authors Khankoeva, A. I., Dukhanin, A. S., Leonidov, N. B., Galenko-Yaroshevskii, P. A., Galygo, D. S.
Format Journal Article
LanguageEnglish
Published New York Springer Nature B.V 01.01.1998
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Summary:Considerable potentiation of antiarrhythmic and antifibrilation effects of two cardiotonic agents, Suphan and the Na-channel blocker L1, was found in the model experimentsin vivo with early occlusion and reperfusion arrhythmias. Suphan in combination with L1 inhibited the rise of intracellular Ca^sup 2+^ (by about 70%) in isolated cardiomyocytes incubated under hypoxic conditions.[PUBLICATION ABSTRACT]
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02496800