ZrO2-pillared clay: An efficient catalyst for solventless synthesis of biologically active multifunctional dihydropyrimidinones

A novel protocol using ZrO2-pillared clay (Zr-PILC), prepared by us as a mild recyclable solid acid catalyst for multicomponent one-pot synthesis of dihydropyrimidinones under solvent free conditions both by thermal and microwave heating using the Bronsted and Lewis acidity (proposed mechanism) of Z...

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Bibliographic Details
Published inCatalysis communications Vol. 7; no. 8; pp. 571 - 578
Main Authors Singh, Vasundhara, Sapehiyia, Varinder, Srivastava, Vivek, Kaur, Sukhbir
Format Journal Article
LanguageEnglish
Published AMSTERDAM Elsevier 01.08.2006
Subjects
Chemistry
Chemistry, Physical
Physical Sciences
Science & Technology
ONE-POT SYNTHESIS
LEWIS-ACID
BIGINELLI REACTION
PROTOCOL
ZrO2-pillared clay
MW
3,4-DIHYDROPYRIMIDIN-2(1H)-ONES
solventless dihydropyrimidinones
ULTRASOUND
CONDENSATION REACTION
nitractin
CONFORMATIONAL-ANALYSIS
3-COMPONENT
monastrol
CHLORIDE
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Summary:A novel protocol using ZrO2-pillared clay (Zr-PILC), prepared by us as a mild recyclable solid acid catalyst for multicomponent one-pot synthesis of dihydropyrimidinones under solvent free conditions both by thermal and microwave heating using the Bronsted and Lewis acidity (proposed mechanism) of Zr-PILC is reported. The efficacy of the procedure is exemplified by the synthesis of biologically active racemic mixture of monastrol and nitractin (a potent lead anti-cancer drug and antibacterial, antiviral drug, respectively). (c) 2006 Elsevier B.V. All rights reserved.
ISSN:1566-7367
1873-3905
DOI:10.1016/j.catcom.2005.12.021