Composite demineralized bone matrix nanofiber scaffolds with hierarchical interconnected networks via eruptive inorganic catalytic decomposition for osteoporotic bone regeneration

• Published in: Journal of materials science & technology Vol. 199; pp. 246 - 259
• Main Authors: Ko, Sung Won, Lee, Joshua, Lee, Ji Yeon, Cho, Jeong Hwi, Lee, Sunny, Jang, Hak Su, Park, Chan Hee, Tae, Hyun Jin, Kim, Cheol Sang, Oh, Young Min
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 10.11.2024
• Subjects: Bone regeneration; Catalytic decomposition; Demineralized bone matrix; Hierarchical networks; Demineralized bone matrix; Hierarchical networks; Bone regeneration; Catalytic decomposition
• ISSN: 1005-0302
• DOI: 10.1016/j.jmst.2024.02.018

•Demineralized bone matrix (DBM)-based nanofibrous scaffolds have been fabricated.•Oxygen-pocketed fibrous DBM scaffolds were prepared by the catalytic decomposition.•Op-fDBM scaffolds could stimulate bone regeneration in the osteoporotic rat models.•Superior bone healing effect was achieved while minimizing expensive DBM content. Demineralized bone matrix (DBM) is one of the standard biomaterials used to fill surgical bone defects in general orthopedic procedures. However, current DBM products come in the form of powder or viscous solutions that fail to mimic the natural hierarchical structure of bone while also using large amounts of valuable material. To overcome this, compact fibrous DBM/polymer (fDBM) composites were prepared via electrospinning. Then, by exploiting the catalytic decomposition of hydrogen peroxide, oxygen pockets are formed in the scaffold imparting it with a hierarchical porous structure similar to bone (Op-fDBM). These pockets created by bubbles of oxygen help give the scaffold a mechanically stable shape while the incorporated DBM supports cell adhesion and growth. In vivo evaluations reveal that fDBM increased bone volume by 41.7 % while Op-fDBM increased bone volume by 68.6 %. Significant increases in regenerated bone volume with the use of minimal amounts of DBM in fiber form go to show the great potential of this work in the field of bone regeneration. [Display omitted]