Assay of paracetamol by oxidation with peroxydisulphate

A new simple and accurate kinetic method for the analysis of paracetamol in pure form and formulations is described. The kinetics parameters have been applied successfully in determining paracetamol when it reacts with persulfate in alkaline medium. The spectrophotometric measurements have been reco...

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Bibliographic Details
Published inPharmaceutica acta Helvetiae Vol. 73; no. 5; pp. 255 - 260
Main Authors Helaleh, Murad I.H, Korenaga, T, Abu-Nameh, Eyad S.M, Jamhour, Rasheed M.A.Q
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 01.02.1999
Elsevier
Subjects
Analysis
Biological and medical sciences
General pharmacology
Medical sciences
Oxidation
Paracetamol
Peroxydisulphate
Pharmacology. Drug treatments
Peroxydisulphate
Paracetamol
Oxidation
Analgesic
Color reaction
Antipyretic
Dosage form
Tablet
Hard capsule
Spectrophotometry
Quantitative analysis
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Summary:A new simple and accurate kinetic method for the analysis of paracetamol in pure form and formulations is described. The kinetics parameters have been applied successfully in determining paracetamol when it reacts with persulfate in alkaline medium. The spectrophotometric measurements have been recorded at 315 nm and found to be valid over the concentration range of 5–30 ppm. The molar absorptivity is equal to 6.55×103 l mol−1 cm−1. The analysis of paracetamol content in mixture of different substances has been carried out without prior separation. The precision and accuracy of the method and the effect of foreign substances have been studied and the results obtained were compared with reference method.
ISSN:0031-6865
DOI:10.1016/S0031-6865(98)00032-6