1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) as a reusable promoting medium for the catalyst-free and green synthesis of dihydropyrano[2,3-c]pyrazole scaffolds

• Published in: Results in Chemistry Vol. 9; p. 101629
• Main Author: Mohamadpour, Farzaneh
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.07.2024; Elsevier
• Subjects: 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP); Catalyst-free; Green protocol; Polyfluorinated alcohol; Reusable medium; Reusable medium; 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP); Catalyst-free; Green protocol; Polyfluorinated alcohol
• ISSN: 2211-7156; 2211-7156
• DOI: 10.1016/j.rechem.2024.101629

A green method of synthesizing dihydropyrano[2,3-c]pyrazole frameworks without the need for a catalyst has been developed through the use of 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as a reusable promoting medium. This simple protocol is advantageous since it doesn’t require a catalyst, saves time, doesn’t waste any raw materials, doesn’t include any hazardous chemicals, and is simple to set up and execute. [Display omitted] A manufactured protocol that is both helpful and free of catalyst has been presented for the production of dihydropyrano[2,3-c]pyrazole frameworks in polyfluorinated alcohol as a reusable promoting medium. All reactions are completed quickly, and the products are obtained in astounding yields. Notably, the convenient approach has remarkable yields, avoids the use of hazardous solvents or reagents, is simple to operate, and only requires one pot. The 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) was extremely stable and could be repeated four times without significant basic alteration or action, making it ideal for large-scale and organic production.