Low- and Intermediate-Grade Lateral Sinus Dural Arteriovenous Fistulas: Factors Affecting the Outcome of Endovascular Treatment over 18-Year Experience in a High-Volume Neurovascular Center

• Published in: American journal of neuroradiology : AJNR Vol. 46; no. 6; pp. 1152 - 1158
• Main Authors: Duan, Guoli, Zhang, Yuhang, Wang, Yang, Li, Zhe, Shang, Chenghao, Chen, Rundong, Zhao, Rui, Yang, Pengfei, Dai, Dongwei, Fang, Yibin, Huang, Qinghai, Hong, Bo, Xu, Yi, Li, Qiang, Liu, Jianmin
• Format: Journal Article
• Language: English
• Published: United States 01.06.2025
• Subjects: Adult; Aged; Central Nervous System Vascular Malformations - diagnostic imaging; Central Nervous System Vascular Malformations - surgery; Central Nervous System Vascular Malformations - therapy; Cerebral Angiography; Embolization, Therapeutic; Endovascular Procedures - methods; Female; Humans; Male; Middle Aged; Recurrence; Retrospective Studies; Risk Factors; Transverse Sinuses - diagnostic imaging; Treatment Outcome
• ISSN: 0195-6108; 1936-959X
• DOI: 10.3174/ajnr.A8622

Lateral sinus dural arteriovenous fistulas (LS-DAVFs) carry a higher rate of recurrence after endovascular treatment (EVT). Our objective was to investigate the independent predictors of recurrence and unfavorable functional outcomes of low-and intermediate-grade LS-DAVFs after EVT. We retrospectively reviewed our database of prospectively collected information for all patients with low- and intermediate-grade LS-DAVFs who underwent EVT from May 2004 to December 2021. Patient demographics, angiographics, treatment, and outcomes were analyzed to identify independent predictors of recurrence and unfavorable outcomes. One hundred and seventeen patients with 117 low- and intermediate-grade LS-DAVFs who underwent EVT were included in this study. The mean age of the patients was 53.0 ± 17.5 years. Immediately complete obliteration was achieved in 103/117 (88%) patients after EVT. Clinical follow-up was available for all 117 patients, with an unfavorable outcome rate of 5.1%. Angiographic follow-up was available in 91 patients (78%). Recurrence occurred in 16 (18%) patients and 8 (6.8%) received retreatment. Contralateral sinus severe stenosis or occlusion was an independent high-risk factor for the unfavorable outcome (OR = 11.7; 95% CI: 1.9-70.9, < .01) and recurrence (OR = 63.8; 95% CI: 10.3-396.5, < .01) for low- and intermediate-grade LS-DAVFs at follow-up. Contralateral sinus severe stenosis or occlusion represents a stronger independent risk factor associated with recurrence and unfavorable outcomes in patients with low- and intermediate-grade LS-DAVFs when the involved ipsilateral sinus was occluded after EVT. For patients with LS-DAVFs, the patency of the contralateral sinus should be considered when making therapeutic decisions.