A novel and facile synthesis of 2-(cyclohexylamino)-6,7-dihydro-3-aryl-1H-indole-4(5H)-ones via a one-pot multi-component reaction

A simple and efficient synthesis of 2-(cyclohexylamino)-6,7-dihydro-3-aryl-1H-indole-4(5H)-ones was achieved via a one-pot multi-component reaction of cyclohexyl isocyanide, an aldehyde, a 1,3-dicarbonyl compound, and ammonium acetate in the presence of a catalytic amount of KHSO4 in acetonitrile. (...

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Bibliographic Details
Published inTetrahedron letters Vol. 49; no. 42; pp. 6101 - 6103
Main Authors Heravi, Majid M., Baghernejad, Bita, Oskooie, Hossein A., Hekmatshoar, Rahim
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 13.10.2008
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
multi-component reaction
OXIDATION
1H-indole-4(5H)-ones
KHSO4
ALDEHYDES
1,3-dicarbonyl compound
cyclohexyl isocyanide
DISCOVERY
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Summary:A simple and efficient synthesis of 2-(cyclohexylamino)-6,7-dihydro-3-aryl-1H-indole-4(5H)-ones was achieved via a one-pot multi-component reaction of cyclohexyl isocyanide, an aldehyde, a 1,3-dicarbonyl compound, and ammonium acetate in the presence of a catalytic amount of KHSO4 in acetonitrile. (C) 2008 Elsevier Ltd. All rights reserved.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2008.08.012