beta-Bromodifluoromethyl beta-enaminoketones: versatile synthetic intermediates for synthesis of CF2-containing compounds
A series of N-aryl beta-bromodifluoromethyl beta-enaminoketones were regioselectively synthesized in good yield by the reaction of N-aryl bromodifluoroacetimidoyl chlorides with methyl ketones. beta-Bromodifluoromethyl beta-enammoketones smoothly cyclized to give a novel class of cyclic (2,2-difluor...
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Published in | Tetrahedron letters Vol. 46; no. 32; pp. 5357 - 5360 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier
08.08.2005
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Subjects | |
Online Access | Get full text |
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Summary: | A series of N-aryl beta-bromodifluoromethyl beta-enaminoketones were regioselectively synthesized in good yield by the reaction of N-aryl bromodifluoroacetimidoyl chlorides with methyl ketones. beta-Bromodifluoromethyl beta-enammoketones smoothly cyclized to give a novel class of cyclic (2,2-difluoro-5-phenyl-furan-3-ylidene)-aryl-amines under basic condition. An intramolecular halophilic substitution mechanism was proposed. (c) 2005 Elsevier Ltd. All rights reserved. |
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ISSN: | 0040-4039 |
DOI: | 10.1016/j.tetlet.2005.06.002 |