Effects of postnatal ganglioside administration and hypoxia-exposure on the dopamine release from striatal slices, the behaviour and the ganglioside pattern of 2-3 months old rats

Neonatal rats were injected with a mixture of bovine brain gangliosides (30 mg/kg body weight, s.c.) immediately before the exposure to hypoxia (pO2 = 10 kPa, 10 hrs daily) from the 2nd to the 11th day of life. At the age of 2-3 months the potential protective or restitutive effect of gangliosides o...

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Published inJournal of neural transmission. General section Vol. 87; no. 2; p. 105
Main Authors Brux, B, Ogawa, K, Berndt, C, Wustmann, C, Fishcer, H D, Lun, A, Abe, T, Gross, J
Format Journal Article
LanguageEnglish
Published Austria 01.06.1992
Subjects
Aging - metabolism
Animals
Animals, Newborn
Behavior, Animal - drug effects
Corpus Striatum - metabolism
Dopamine - metabolism
Gangliosides - metabolism
Gangliosides - pharmacology
Hypoxia - metabolism
Hypoxia - psychology
In Vitro Techniques
Male
Potassium - pharmacology
Rats
Rats, Inbred Strains
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Summary:Neonatal rats were injected with a mixture of bovine brain gangliosides (30 mg/kg body weight, s.c.) immediately before the exposure to hypoxia (pO2 = 10 kPa, 10 hrs daily) from the 2nd to the 11th day of life. At the age of 2-3 months the potential protective or restitutive effect of gangliosides on the radiolabelled dopamine release from striatal slices and on the conditioned avoidance learning was studied. No change in the content and the pattern of gangliosides of the rat striata was found after exposure to hypoxia and ganglioside administration, respectively. Both hypoxia exposure and ganglioside treatment of controls increased the dopamine release whereas hypoxic animals treated with gangliosides showed a diminished release. Hypoxia-induced impaired conditioned avoidance learning was improved by ganglioside treatment. The changed release of dopamine and the altered behavioural performance after ganglioside treatment alone indicate the necessity of a very cautious application of gangliosides to the developing brain.
DOI:10.1007/BF01245012