Morphogenesis of chronic lung lesions under the influence of proteolytic enzymes

Acute and chronic pathological processes induced in murine lungs by influenza virus or intranasal administration of proteolytic enzymes chymotrypsin and proteinase K were compared. Histologic and electron microscopic analysis showed that a number of characteristics of these two processes were simila...

Full description

Saved in:
Bibliographic Details
Published inBulletin of experimental biology and medicine Vol. 128; no. 1; pp. 760 - 763
Main Authors Zarubaev, V V, Sukhinin, V P
Format Journal Article
LanguageEnglish
Published New York Springer Nature B.V 01.07.1999
Subjects
Enzymes
Influenza virus
Lungs
Mycoplasma
Online AccessGet full text

Cover

More Information
Summary:Acute and chronic pathological processes induced in murine lungs by influenza virus or intranasal administration of proteolytic enzymes chymotrypsin and proteinase K were compared. Histologic and electron microscopic analysis showed that a number of characteristics of these two processes were similar. These characteristics included serosanguineous lung edema on days 1-5 postinfection, infiltration of lung tissue with cell elements, metaplasia of bronchial epithelium, and presence of mycoplasma in chronic pneumonia foci. These parameters persisted during 150 days of the experiment without regression. The results suggest the key role of primary cell destruction and proteolytic activity enhancement in the development of chronic influenza-induced pneumonia.[PUBLICATION ABSTRACT]
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02433337