Association of P wave dispersion and left ventricular diastolic dysfunction in non-dipper and dipper hypertensive patients

• Published in: Anadolu kardiyoloji dergisi : AKD Vol. 14; no. 3; pp. 251 - 255
• Main Authors: Tosu, Aydın Rodi, Demir, Şerafettin, Kaya, Yüksel, Selçuk, Murat, Akdağ, Serkan, Işık, Turgay, Arın, Can Baba, Özdemir, Mahmut, Akkuş, Oğuz
• Format: Journal Article
• Language: English
• Published: Turkey Kare Publishing 01.05.2014
• Subjects: Arrhythmias, Cardiac - physiopathology; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Cross-Sectional Studies; Echocardiography; Electrocardiography; Female; Humans; Hypertension; Male; Middle Aged; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - physiopathology
• ISSN: 1302-8723; 2149-2263; 1308-0032; 2149-2271
• DOI: 10.5152/akd.2014.4668

Objective of this study was to investigate the correlation between P wave dispersion and left ventricular diastolic function, which are associated with the increased cardiovascular events in patients with dipper and non-dipper hypertensive (HT). Eighty sex and age matched patients with dipper and non-dipper HT, and 40 control subject were included in this observational cross-sectional study. P wave dispersion was measured through electrocardiography obtained during the admission. The left ventricular LV ejection fraction was measured using the modified Simpson's rule by echocardiography. In addition, diastolic parameters including E/A rate, deceleration time (DT) and isovolumetric relaxation time (IVRT) were recorded. Independent samples Bonferroni, Scheffe and Tamhane tests and correlation test (Spearman and Pearson) were used for statistical analysis. P wave dispersion was found to be significantly increased in the non-dipper than in the dipper group (56.0±5.6 vs. 49.1±5.3, p<0.001). Pmax duration was found significantly higher (115.1±5.6 vs. 111.1±5.8, p=0.003) and Pmin duration significantly lower (59.0±5.6 vs. 62.3±5.3, p=0.009) in the non-dippers. Correlation analysis demonstrated presence of moderate but significant correlation between P-wave dispersion and left ventricular mass index (r=0.412, p=0.011), IVRT (r=0.290 p=0.009), DT (r=0.210, p=0.052) and interventricular septum thickness (r=0.230 p=0.04). P wave dispersion and P Max were found to be significantly increased and P min significantly decreased in the non-dipper HT patients compared to the dipper HT patients. P-wave dispersion is associated with left ventricular dysfunction in non-dipper and dipper HT.