Effects of （-）-Epigallocatechin gallate on some protein factors involved in the epidermal growth factor receptor signaling pathway

• Published in: Journal of Nanjing Medical University Vol. 23; no. 5; pp. 293 - 299
• Main Authors: Huang, Yinjiu, Xu, Ruiqing, Song, Baoan, Yang, Song, Zhao, Li, Wu, Shouwei
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.09.2009
• Subjects: (−)-Epigallocatechin gallate (EGCG); EGCG; epidermal growth factor receptor (EGFR); Signaling pathway; 信号转导通路; 信号通路; 受体酪氨酸激酶; 哺乳动物细胞; 没食子酸酯; 蛋白质; 表皮生长因子受体; Signaling pathway; (−)-Epigallocatechin gallate (EGCG); epidermal growth factor receptor (EGFR)
• ISSN: 1007-4376; 1876-4819
• DOI: 10.1016/S1007-4376(09)60073-3

（-）-Epigallocatechin gallate （EGCG）, a major polyphenolic constituent of green tea, can inhibit activity of specific receptor tyrosine kinases （RTKs） and related downstream signal transduction pathways, resulting in the control of unwanted cell proliferation. The epidermal growth factor receptor （EGFR） signaling pathway is one of the most important pathways that regulates growth, survival,proliferation and differentiation in mammalian cells. This review addresses the effects of EGCG on some protein factors involved in the EGFR signaling pathway in a direct or indirect manner. Based on our understanding of the interaction between EGCG and these factors, and based on their structures, EGCG could be used as a lead compound for designing and synthesizing novel drugs with significant biological activity.