Short-term outcome of total knee replacement in a patient with hemophilia: A case report and review of literature

Hemophilia A is a rare inherited bleeding disorder caused by mutations in the factor VIII gene. This clotting factor plays an intrinsic role in the blood coagulation pathway. Patients with hemophilia may develop orthopedic manifestations such as hemarthrosis, but multiple malunion of fractures over...

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Bibliographic Details
Published inWorld journal of clinical cases Vol. 11; no. 12; pp. 2788 - 2795
Main Authors Yin, De-Long, Lin, Jia-Min, Li, Yuan-Hui, Chen, Peng, Zeng, Mian-Dong
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 26.04.2023
Subjects
Case Report
Multiple malunion of fractures
Case report
Coagulation factor replacement
Hemophiliac arthropathy
Total knee replacement
Hemophilia
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Summary:Hemophilia A is a rare inherited bleeding disorder caused by mutations in the factor VIII gene. This clotting factor plays an intrinsic role in the blood coagulation pathway. Patients with hemophilia may develop orthopedic manifestations such as hemarthrosis, but multiple malunion of fractures over the knee is rare and difficult to treat. We report a patient with hemophilia A who developed severe knee osteoarthritis along with fracture malunion and nonunion. Total knee replacement was performed using a custom-made modular hinged knee prosthesis (cemented) equipped with extended distal and proximal stems. At 3 years' follow-up, the patient exhibited excellent clinical function and remained satisfied with the surgical outcome. Surgical intervention was accompanied by rigorous coagulation factor replacement. This case highlights various unique scenarios specific to individuals with hemophilia and fracture deformity.
Bibliography:Corresponding author: Mian-Dong Zeng, Doctor, Chief Doctor, Chief Physician, Department of Orthopedic, The Third Affiliated Hospital of Guangzhou Medical University, No. 63 Duobao Road, Guangzhou 510150, Guangdong Province, China. 13527611112@139.com
Author contributions: Yin DL and Zeng MD analyzed and interpreted the patient data; Lin JM assistance make plan for supplementation of clotting factors; Chen P performed the following up and collected the image data; Yin DL and Lin JM were a major contributor in writing the manuscript; Zeng MD, Li YH and Yin DL participated in the operation; all authors have read and approve the final manuscript.
ISSN:2307-8960
2307-8960
DOI:10.12998/wjcc.v11.i12.2788