Antifungal activity of Nepeta rtanjensis essential oil

• Published in: Journal of the Serbian Chemical Society Vol. 73; no. 10; pp. 961 - 965
• Main Authors: Grbic-Ljaljevic, Milica, Stupar, Milos, Vukojevic, Jelena, Sokovic, Marina, Misic, Danijela, Grubisic, Dragoljub, Ristic, Mihailo
• Format: Journal Article
• Language: English
• Published: Serbian Chemical Society 2008
• Subjects: antifungal activity; essential oil; Nepeta rtanjensis
• ISSN: 0352-5139; 1820-7421
• DOI: 10.2298/JSC0810961G

The chemical composition and antifungal activity of the essential oil of an endemic Serbian plant Nepeta rtanjensis Diklic & Milojevic was studied. The essential oil was isolated from cultivated plants. Inhibition of mycelia growth of five micromycetes, two Alternaria species originally isolated from N. rtanjensis, Cladosporium cladosporoides, Trichoderma viride and Bipolaris spicifera, were tested using the agar dilution method. The essential oil of N. rtanjensis, the main component of which was 4aa,7a,7ab-nepetalactone, showed strong antifungal activity against all the tested micromycetes. The minimum inhibitory concentration of N. rtanjensis essential oil ranged from 0.6 to 1.4 ?g mL-1. The fungi most sensitive to the tested oil were Alternaria species, while Trichoderma viride was the most resistant. U ovom radu prezentovan je hemijski sastav i antifungalna aktivnost etarskog ulja endemicne biljke Nepeta rtanjensis Diklic & Milojevic. Etarsko ulje je izolovano iz kultivisanih biljaka. Inhibicija micelijalnog rasta pet mikromiceta, dve vrste roda Alternaria, izolovane sa N. rtanjensis, Cladosporium cladosporioides, Trichoderma viride i Bipolaris spicifera, testirana je makrodilucionom metodom. Etarsko ulje N. rtanjensis, cija je glavna komponenta 4a?,7?,7ab-nepetalakton pokazuje jaku antifungalnu aktivnost u odnosu na sve testirane mikromicete. Minimalna inhibitorna koncentracija (MIC) etaskog ulja bila je u rasponu od 0,6 ?g mL-1 do 1,4 ?g mL-1. Najvecu osetljivost na testirano ulje pokazale su vrste roda Alternaria dok je Trichoderma viride bila najotpornija.