Antimicrobial Susceptibility Profile of Methicillin-Resistant Staphylococcus Aureus Isolated from Clinical Samples at Bac Ninh Provincial General Hospital, Vietnam

• Published in: Infection and drug resistance Vol. 17; pp. 4113 - 4123
• Main Authors: An, Nguyen Van, Nguyen, Hai Thi, Nguyen Le, Van, Thu Van, Ha Thi, Hai, Nguyen Minh, Luong, Vu Huy, Nguyen, Vinh Thi Ha, Pham, Hoa Quynh, Le, Hung Van, Hung, Dinh Viet, Kien, Hoang Trung, Le, Minh Nhat, Viet, Nguyen Hoang, Thuc, Luong Cong, Thang, Ta Ba, Tien, Tran Viet, Hoang, Le Huy, Tram, Nguyen Thuy, Le, Tuan Dinh, Son, Nguyen Tien, Le, Hai Ha Long
• Format: Journal Article
• Language: English
• Published: New Zealand Dove 01.09.2024; Dove Medical Press
• Subjects: antibiotic resistance; mdr; mrsa; Original Research; staphylococcus aureus; vietnam; Vietnam; MDR; antibiotic resistance; Staphylococcus aureus; MRSA
• ISSN: 1178-6973; 1178-6973
• DOI: 10.2147/IDR.S477031

, including methicillin-resistant (MRSA) strain, can become resistant to all classes of clinically available antibiotics and causes skin infections and severe infections in the lungs, heart, and bloodstream. The study aimed to evaluate antimicrobial susceptibility patterns and MRSA exhibiting multidrug resistance obtained through a microbiological culture of clinical specimens at Bac Ninh Provincial General Hospital in Bac Ninh Province, Vietnam. We employed a cross-sectional analysis at Bac Ninh Provincial General Hospital in Vietnam. 15,232 clinical samples from inpatients were examined. isolates were identified using established protocols and tested for MRSA and antibiotic susceptibility. Data was analyzed using R software, with statistical calculations to assess associations between variables. was isolated from 417 samples (2.7%), with 77.2% being MRSA and 22.8% methicillin-susceptible (MSSA). Significant sources of MRSA were wounds (64.6%) and the surgical unit (50%) according to sample types and hospital wards, respectively. showed high resistance rates, the highest being azithromycin (83.2%), and was fully susceptible to vancomycin. Among 294 multidrug-resistant (MDR) strains, the prevalence was 82.0% in MRSA and 18.0% in MSSA. The study highlights widespread antimicrobial resistance among MRSA isolates from a provincial hospital in Vietnam, emphasizing the urgent need for antibiotic surveillance, formulation of antibiotic policies, and preventive measures to tackle the increasing prevalence of multidrug-resistant MRSA.